Hematologic Cancers in Children: Types, Symptoms, Diagnosis, Treatment & Support Challenges in India

Blood cancers impact the formation and functioning of your child’s blood cells. While regular blood cells will reproduce and die, cancerous blood cells do not die and instead continuously reproduce and push out the healthy blood cells. The two most common types of hematologic cancers in children are leukemia and lymphoma. Acute Lymphoblastic Leukemia (ALL) — more commonly called blood cancer is the most prevalent.

A diagnosis of blood cancer in a child can be emotionally overwhelming for parents. It’s natural to feel confused by the medical terms and the treatment plans. However, understanding what’s happening can help parents feel more in control and give them the strength needed during the treatment journey.

The word “Leukemia” comes from the Greek words leucos (white) and haima (blood), meaning an excess of white blood cells. In simple terms, leukemia is cancer of the white blood cells.

The bone marrow is the soft, spongy tissue inside our bones. It makes three important types of blood cells:

In blood cancer, the bone marrow starts producing abnormal white blood cells in large numbers, called blasts. These immature cells crowd out the healthy blood cells, just like weeds in a garden, stopping flowers from growing. As a result, children may develop:

Causes of Blood Cancer in Children
Most parents wonder what caused their child’s illness. However, in most cases, there is no known reason. Some rare cases may be linked to genetic conditions like Down syndrome. While exposure to radiation and chemicals like pesticides has been studied, no direct cause has been confirmed. It’s important to note that blood cancer is not contagious and cannot spread from one child to another.

However, many of these symptoms are common in kids and don’t always mean cancer. Still, if these symptoms persist, consult a doctor.

The first test is usually a complete blood count (CBC). It checks the levels of blood cells and may show abnormal white cells. However, sometimes the CBC may appear normal. To confirm leukemia, doctors would do a bone marrow test, which involves collecting a small sample of marrow, usually from the hip bone. This is done under sedation or anesthesia and causes only temporary discomfort.

Other tests include:

Treatment usually begins with the treatment of early symptoms such as anemia (low red blood cells), bleeding, or infections. Then, a combination of treatments can be employed based on the child’s condition:

Chemotherapy: These are drugs taken orally or by IV (into a vein). They target rapidly growing cells such as cancer cells. They can also target healthy cells, causing side effects.

Intrathecal chemotherapy: Drugs are directly injected into the space surrounding the spinal cord to treat cancer cells in the brain and spinal fluid.

Radiation therapy: Special energy beams, such as X-rays, are directed to kill cancer cells. This can also relieve pain due to inflamed organs or bone marrow pressure.

Stem cell or bone marrow transplant: Intensive chemotherapy (and, at times, radiation) is first administered to destroy the cancer cells in the bone marrow. Healthy stem cells from a donor are then infused through an IV. These cells migrate to the bone marrow and begin producing healthy blood cells again.

Immunotherapy (Biological therapy): Specific antibodies are employed to enable the immune system to identify and kill cancer cells. Some also aid in the delivery of medicine straight to the cancerous tissue.

Supportive medicines: Medications can be administered to control side effects like nausea, pain, or to guard healthy cells during treatment.

Blood transfusions: Employed to replace shed red blood cells or platelets.

Antibiotics: These are administered to prevent or cure infections during therapy when the immune system is compromised.

Follow-up care: Checkups are essential to monitor how well the treatment is progressing, detect if the cancer comes back, and observe for any late side effects.

Not always. Most children with ALL respond well to chemotherapy alone. A bone marrow transplant is considered only in cases where the child doesn’t respond well to chemo or has high-risk features in their test reports.

In India, childhood blood cancer care is improving, but families still face many challenges. These include:

However, the good news is that support systems are growing:

Being informed and seeking support early can make a big difference in the outcome and overall experience for both the child and their family.